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Building effective and long-term treatment strategies requires genetic modulations that are stable and long lasting.

Adeno-associated virus (AAV) offers several significant advantages when compared with other gene delivery systems.

In-person sexuality education programs are helpful, but they are unlikely to rapidly accommodate teens and young adults in a moment of crisis.For example, AAV serotypes transduce different cells and neurons, do not provoke toxicity in humans, provide long-term expression, there is a wide selection of available promoters and there are continuous improvements in vector capsid engineering.More relevant to this study, AAV-mediated retrograde transduction approaches selectively transduce CSMN within the complex and heterogeneous structure of the motor cortex, without affecting other neurons or cell types.Evidence suggests that technologies such as instant messaging (IM) and text messaging may be effective ways to provide teens and young adults with sexual and reproductive health information.In September 2010, Planned Parenthood Federation of America launched a text and IM program designed to provide immediate answers to urgent sexual and reproductive health questions from a reliable and confidential source and to link young people to sexual and reproductive health services if needed.

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